California Bids > Bid Detail

TECHNOLOGY/BUSINESS OPPORTUNITY Lattice Spray Substrates for Mass Spectrometry

Agency:
Level of Government: Federal
Category:
  • 66 - Instruments and Laboratory Equipment
  • 99 - Miscellaneous
Opps ID: NBD00159593909615689
Posted Date: Feb 16, 2023
Due Date: Feb 17, 2023
Solicitation No: IL-13504
Source: https://sam.gov/opp/45c1020857...
TECHNOLOGY/BUSINESS OPPORTUNITY Lattice Spray Substrates for Mass Spectrometry
Active
Contract Opportunity
Notice ID
IL-13504
Related Notice
Department/Ind. Agency
General Information
  • Contract Opportunity Type: Special Notice (Original)
  • All Dates/Times are: (UTC-08:00) PACIFIC STANDARD TIME, LOS ANGELES, USA
  • Original Published Date: Feb 16, 2023 12:40 pm PST
  • Original Response Date: Feb 17, 2023 12:00 am PST
  • Inactive Policy: Manual
  • Original Inactive Date: Mar 20, 2023
  • Initiative:
    • None
Classification
  • Original Set Aside:
  • Product Service Code:
  • NAICS Code:
  • Place of Performance:
    Livermore , CA
    USA
Description

Opportunity:



Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract no. DE-AC52-07NA27344 (Contract 44) with the U.S. Department of Energy (DOE), is offering the opportunity to enter into a collaboration partnership to further develop and commercialize its novel lattice spray substrates for mass spectrometry.



Background:



Liquid Chromatography Mass Spectrometry (LC-MS) is a traditional analytical technique for the analysis of various molecules (particularly in complex samples) including chemical weapon agents and biotoxins. The drawbacks of LC-MS are the technique is time consuming, uses large amounts of solvents and requires technical expertise.



An alternative is direct ionization mass spectroscopy, which involves a faster simple, all-in-one sample processing and where ionization replaces the protracted liquid chromatography step. Paper Spray Mass Spectrometry (PS-MS) is the current state-of-the-art in direct ionization mass spectrometry. However, it is limited because it requires chromatography paper to be used as the substrate. Paper is made of cellulose – a single material with the same surface energy – thus not tunable and restricts the kind of molecules that could be analyzed.



To expand the range of molecules from the most complex (e.g. physiological fluids like blood and urine) to those that are incompatible with paper spray ionization (e.g. hydrophilic or large proteins), the substrate used in direct ionization mass spectrometry would need to advance beyond chromatography paper.



Description:



To get the best of both worlds – the sensitivity of LC-MS with the speed of PS-MS – and a functional substrate that can maintain sample integrity, LLNL researchers looked to 3D printing. They have patented a novel approach to create lattice spray substrates for direct ionization mass spectroscopy using 3D-printing processes.



Using a combination of Projection Micro Stereolithography (PµSL), Large Area Projection Micro Stereolithography (LAPµSL), and Lattice Fluidics, sample substrates (based on the octet-truss microlattice) with pore sizes in the desired range (10-100µm) for direct ionization mass spectrometry can be produced. The manufacturing process allows for different materials to be used in fabrication and full control of multiscale structures so that the substrate can be tuned for specific analytes of interest as well as optimized for various sample matrices (e.g. blood or other fluids, environmental samples).



Advantages/Benefits:




  • Combine sample storage, transport, and mass spectrometry processing

  • Field deployable

  • Moves society closer to personalized medicine



Potential Applications:




  • Field collection of environmental (soil, water) and physiological samples (e.g. from remote locations)

  • Monitoring of chemical and biological agents in humans and environmental samples

  • Forensics and clinical toxicology

  • Hospitals, clinical research, personalized medicine

  • Food, beverage and drug integrity and safety



Development Status:



U.S. Patent Application Publication No. 2022/0262613 Systems and Methods Lattice Spray Substrates for Mass Spectrometry published 8/18/2022



Current stage of technology development: TRL 2



LLNL is seeking industry partners with a demonstrated ability to bring such inventions to the market. Moving critical technology beyond the Laboratory to the commercial world helps our licensees gain a competitive edge in the marketplace. All licensing activities are conducted under policies relating to the strict nondisclosure of company proprietary information.





Please visit the IPO website at https://ipo.llnl.gov/resources for more information on working with LLNL and the industrial partnering and technology transfer process.





Note: THIS IS NOT A PROCUREMENT. Companies interested in commercializing LLNL's Lattice Spray Substates for Mass Spectrometry should provide a written statement of interest, which includes the following:





1. Company Name and address.



2. The name, address, and telephone number of a point of contact.



3. A description of corporate expertise and/or facilities relevant to commercializing this technology.





Written responses should be directed to:



Lawrence Livermore National Laboratory



Innovation and Partnerships Office



P.O. Box 808, L-779



Livermore, CA 94551-0808



Attention: IL-13504





Please provide your written statement within thirty (30) days from the date this announcement is published to ensure consideration of your interest in LLNL's Lattice Spray Substates for Mass Spectrometry.


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